Pubblicazioni Top in Cardiologia

The year in cardiovascular medicine 2024: the top 10 papers in heart failure.

The year in cardiovascular medicine 2024: the top 10 papers in heart failure. Solomon SD, McMurray JJV, Vaduga,et al.Finerenone in heart failure with mildly reduced or preserved ejection fraction.
N Engl J Med 2024;391:1475–85.
Nei pazienti con scompenso cardiaco a FE moderatamente depressa o conservata, finerenone ha ridotto rispetto al placebo un endpoint composito di morte per causa cardiovascolare ed eventi correlati a peggioramento dello scompenso.

Kosiborod MN, Petrie MC, Borlaug BA, et al. Semaglutide in patients with obesity-related heart failure and type 2 diabetes. N Engl J Med 2024;390:1394–407.
Nei pazienti obesi con diabete di tipo 2 e con scompenso a FE conservata, la semaglutide ha ridotto significativamente, rispetto al placebo a 1 anno di follow-up, il peso, i sintomi e le limitazioni fisiche correlate allo scompenso.

Packer M, Zile MR, Kramer CM, et al. Tirzepatide for heart failure with preserved ejection fraction and obesity. N Engl J Med 2024. Online ahead of print.
Nei pazienti obesi con scompenso a FE conservata, tirzepatide ha ridotto rispetto al placebo un endpoint composito di morte cardiovascolare e peggioramento dello scompenso, migliorando lo stato di salute.

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THE YEAR IN CARDIOVASCULAR MEDICINE 2023: THE TOP 10 PAPERS IN HEART FAILURE AND CARDIOMYOPATHIES.

1.     Brugts JJ, Radhoe SP, Clephas PRD, Aydin D, van Gent MWF, Szymanski MK,  et  al.  Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial. Lancet 2023;401: 2113–23.

Haemodynamic  monitoring substantially improved quality of life and reduced heart failure hospitalisations in patients with moderate-to-severe heart failure treated according to contemporary guidelines. These findings contribute to the aggregate evidence for this technology and might have implications for guideline recommendations and implementation of remote pulmonary artery pressure monitoring. 

2.     Mentz RJ, Anstrom KJ, Eisenstein EL, Sapp S, Greene SJ, Morgan S, et al. Effect of torsemide vs furosemide after discharge on all-cause mortality in patients hospitalized with heart failure: the TRANSFORM-HF randomized clinical trial. JAMA 2023;329:214–23.

Among patients discharged after hospitalization for heart failure, torsemide compared with furosemide did not result in a significant difference in all-cause mortality over 12 months. However, interpretation of these findings is limited by loss to follow-up and participant crossover and nonadherence.

3. Yeoh S E, Osmanska J, Petrie MC, Brooksbank KJM, Clark AL, Docherty KF, et al. Dapagliflozin versus metolazone in heart failure resistant to loop diuretics. Eur Heart J 2023;44:2966–77.

In patients with heart failure and loop diuretic resistance, dapagliflozin was not more effective at relieving congestion than metolazone. Patients assigned to dapagliflozin received a larger cumulative dose of furosemide but  experienced less biochemical upset than those assigned to metolazone.

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