Pubblicazioni Top in medicina cardiovascolare nel 2022: cardiovascular imaging

1. Brener MI, Lurz P, Hausleiter J, Rodés-Cabau J, Fam N, Kodali SK, et al. Right ventricularpulmonary arterial coupling and afterload reserve in patients undergoing transcatheter tricuspid valve repair. J Am Coll Cardiol 2022;79:448–461. https://doi.org/10.1016/j. jacc. 2021.11.031. Right ventricular-Pulmonary arterial coupling is a powerful, independent predictor of allcause mortality in patients with tricuspid regurgitation undergoing transcatheter tricuspid valve repair. These data suggest that the TAPSE/Pulmonary artery systolic pressure ratio can inform patient selection and prognostication following transcatheter tricuspid valve repair.

2. Cahill TJ, Pibarot P, Yu X, Babaliaros V, Blanke P, Clavel MA, et al. Impact of right ventriclepulmonary artery coupling on clinical outcomes in the PARTNER 3 trial. JACC Cardiovasc Interv 2022;15:1823–1833. https://doi.org/10.1016/j. jcin.2022.07.005. In patients with symptomatic severe aortic stenosis at low surgical risk undergoing trans-catheter aortic valve replacement or surgical aortic valve replacement, baseline right ventricle – Pulmonary artery uncoupling defined by TAPSE/Pulmonary artery systoli pressure ≤0.55 mm Hg-was associated with adverse clinical outcomes at 2 years, including all-cause mortality, cardiovascular mortality, and rehospitalization.

3. Smaeilzadeh M, Urzua Fresno CM, Somerset E, Shalmon T, Amir E, Fan CS, et al. A combined echocardiography approach for the diagnosis of cancer therapy-related cardiac dysfunction in women with early-stage breast cancer. JAMA Cardiol 2022;7:330–340. https://doi. org/10.1001/jamacardio.2021.5881. Using Cardiac Magnetic Resonance cancer therapy–related cardiac dysfunction (CTRCD) as the reference standard, these data suggest that a sequential approach combining echocardiographic 3-D LVEF with 2-D GLS and 2-D peak systolic global longitudinal strain may provide a timely diagnosis of CTRCD during routine CTRCD surveillance with greater accuracy than using these measures individually.

4. Martinez-Naharro A, Patel R, Kotecha T, Karia N, Ioannou A, Petrie A, et al. Cardiovascular magnetic resonance in light-chain amyloidosis to guide treatment. Eur Heart J 2022;43:4722– 4735. doi: 10.1093/eurheartj/ehac363. Cardiac amyloid deposits frequently regress following chemotherapy, but only in patients who achieve complete response or very good partial response. Changes in extracellular volume predict outcome after adjusting for known predictors.

5. Garg P, Gosling R, Swoboda P, Jones R, Rothman A, Wild JM, et al. Cardiac magnetic resonance identifies raised left ventricular filling pressure: prognostic implications. Eur Heart J 2022;43:2511–2522. https://doi. org/10.1093/eurheartj/ehac207. Cardiac amyloid deposits frequently regress following chemotherapy, but only in patients who achieve complete response or very good partial response. Changes in extracellular volume predict outcome after adjusting for known predictors.

6. Leyva F, Zegard A, Okafor O, Foley P, Umar F, Taylor RJ, et al. Myocardial fibrosis predicts ventricular arrhythmias and sudden death after cardiac electronic device implantation. J Am Coll Cardiol 2022;79:665–678. https://doi.org/10.1016/j.jacc.2021.11.050. A physiological cardiac magnetic resonance (CMR) model can estimate left ventricular filling pressure (LVFP) in patients with suspected heart failure. In addition, CMRmodelled LVFP has a prognostic role.

7. Maurovich-Horvat P, Bosserdt M, Kofoed KF, Rieckmann N, Benedek T, et al. DISCHARGE Trial Group, CT or invasive coronary angiography in stable chest pain. N Engl J Med 2022;386:1591–1602. https://doi. org/10.1056/NEJMoa2200963. Among patients referred for invasive coronary angiography (ICA) because of stable chest pain and intermediate pre-test probability of coronary artery disease, the risk of major adverse cardiovascular events was similar in the computer tomography (CT) group and the ICA group. The frequency of major procedure-related complications was lower with an initial CT strategy.

8. Fukui M, Bapat VN, Garcia S, Dworak MW, Hashimoto G, Sato H, et al. Deformation of transcatheter aortic valve prostheses: implications for hypoattenuating leaflet thickening and clinical outcomes. Circulation 2022;146:480–493. https://doi.org/10.1161/ CIRCULATIONAHA.121.058339. Non-uniform expansion of TAVI prostheses resulting in frame deformation, asymmetric leaflet, and smaller neo-sinus volume is related to occurrence of hypo-attenuating leaflet thickening in patients who undergo TAVI. These data may have implications for both prosthesis valve design and deployment techniques to improve clinical outcomes for these patients.

9. Driessen RS, van Diemen PA, Raijmakers PG, Knuuti J, Maaniitty T, Underwood SR, et al. Functional stress imaging to predict abnormal coronary fractional flow reserve: the PACIFIC 2 study. Eur Heart J 2022;43:3118–3128. https://doi.org/10.1093/eurheartj/ehac286. In this prospective head-to-head comparative study, SPECT, PET, and cardiac magnetic resonance did not show a significantly different accuracy for diagnosing FFR defined significant coronary artery disease in patients with prior PCI and/or myocardial infarction. Overall diagnostic performances, however, were discouraging and the additive value of non-invasive imaging in this high-risk population is questionable. 10. Donà C, Nitsche C, Koschutnik M, Heitzinger G, Mascherbauer K, Kammerlander AA, et al. Unveiling cardiac amyloidosis, its characteristics, and outcomes among patients with MR undergoing transcatheter edge-to-edge MV repair. JACC Cardiovasc Interv 2022;15:1748–1758. https://doi. org/10.1016/j.jcin.2022.06.009. Dual pathology of mitral regurgitation (MR) and cardiac amyloidosis is common in elderly patients with MR undergoing transcather edge-to-edge repair and has worse postinterventional outcomes compared with lone MR.